I want to support Apple Silicon, obviously. (TBF, I can't blame them for this, since this does work on a Mac, for at least a simple build.) As a result, the people who started 8 hours before I did picked CMake and vcpkg to handle build system generation and 3rd party dependencies. The present results add to the pharmacological characterization of muscle nAChRs and indicate that quinine is effective at the muscular nAChRs close to therapeutic blood concentrations required for the therapy and prophylaxis of nocturnal leg cramps, suggesting that the clinically proven efficacy of quinine could be based on targeting nAChRs."""Īgain, none of this is really my choice: our project is multi-platform (specifically, at this time, Windows and macOS). Therefore, quinine is proposed to inhibit ACh-evoked currents in a non-competitive manner. The efficacy of the block by quinine was independent of the ACh concentration. At the fetal nAChR composed of ** subunits, the IC50 for quinine was found to be 2.30 **M. It could be demonstrated that the compounds blocked acetylcholine (ACh)-evoked responses in Xenopus laevis oocytes expressing the adult nAChR composed of αβ□δ subunits in a concentration-dependent manner, with a ranked potency of quinine (IC50 = 1.70 **M), chloroquine (IC50 = 2.22 **M) and quinidine (IC50 = 3.96 **M). Here we report the effects of the quinoline derivatives quinine, quinidine, and chloroquine on human adult and fetal muscle nicotinic acetylcholine receptors (nAChRs). Quinine was first isolated in 1820 and is still acknowledged in the therapy of chloroquine-resistant falciparum malaria in lower dosage quinine has been used as treatment for leg cramps since the 1940s. Cinchona bark has been used as an antimalarial agent for more than 400 years. S = """The genus Cinchona is known for a range of alkaloids, such as quinine, quinidine, cinchonine, and cinchonidine. I'm wondering how is possible for a platform-independent language that runs on Linux but not on Mac. But when I run the same code on my Linux machine or on Windows it works completely fine. When I run that code on MacOS, it shows me an error. I have a Python code that parses XML string.
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